Researchers have shown that a protein called HKDC1 is a new target of another protein, TFEB, and plays key roles in maintaining the stability of both mitochondria and lysosomes. HKDC1 is essential for ...

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

Defective proteins have to be eliminated to maintain good health, and when they aren't removed and they build up, serious disorders can occur. Both Alzheimer's and Parkinson's disease have long been ...

To speed up their growth, leukemia cells typically activate the recycling of cellular structures -- enabling them to dispose of defective components and better supply themselves with building ...

CHICAGO (CBS) -- Lysosomes – membrane-bound structures within each cell of humans and all animals – are sometimes known as the cells' "garbage disposals" or "cellular janitors." The structures are ...

To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes - critically important ...

The distribution of a number of membrane proteins on plasmalemmal microdomains (microvilli, coated pits) and in endosomes and lysosomes of the proximal tubule epithelial cell was determined in normal ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby ...