A new study reports on a promising new approach to prevent and treat cholesterol gallstone disease (CGD) that reduces the biliary output of cholesterol via activation of receptors present in tissues ...

Age, female gender and obesity are well-known risk factors for cholesterol gallstone disease, which has an incidence of up to 15% in the Western world. The association between gallstones and obesity ...

(A) ABC transporters: The normal functioning of ABCG8/ABCG5, ABCB4, and ABCB11 enables the transport of cholesterol, bile acids, and lipids into bile (left). Mutations in any of these result in ...

In 1981, the National Cooperative Gallstone Study established the efficacy and safety of CDCA therapy. [26] Although gallstones could be dissolved by oral administration of CDCA, its efficacy was low.

Sticky meshworks of DNA and proteins extruded by white blood cells called neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation, researchers ...

Q. In prior columns, you talked about the use of medications to lower cholesterol and that guidelines that were introduced in 2013 have been controversial. Is there anything new to know? A. Yes. Just ...

Gallstones are small stones that form within the gallbladder and are usually made up of cholesterol. In the majority of people with gallstones, the stones do not cause symptoms or require treatment.

Gallstones are supersaturated, pebble-like deposits of bile inside the gallbladder. They can be as small as a grain of sand or as big as a golf ball and can occur as a single stone or as a collection ...

Gallstones develop in response to an imbalance of lipids in bile, the digestive fluid produced in the liver. A compound that restores the balance prevents gallstone formation in mouse models (pages ...

Philadelphia, PA, March 13, 2017 - According to current estimates, 20 to 25 million Americans have or will develop gallstones, representing almost 15% of adults. Although only a small percentage of ...