Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night ...

SportsLine's model simulated Indianapolis vs. San Francisco on 'MNF' 10,000 times and reveals its NFL picks today ...

Tonight’s week 16 MNF game features two teams heading in opposite directions. In the first half of the season, the 49ers ...

Monday Night Football player prop projections from Covers. Our best MNF computer picks for 49ers vs. Colts tonight.

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

Our Philip Rivers picks and predictions aren't bullish on the aged Colts QB tapping into the fountain of youth on Monday ...

Head Coach Kyle Shanahan and the Niners now control their fate in their pursuit of the NFC West crown and the top overall seed in the NFC. The scary part for the rest of the NFC is San Francisco is ...

Pittsburgh Steelers vs Miami Dolphins picks, predictions, odds, win probabilities for NFL Week 15 Monday Night Football game ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

The Colts played it safe through the air in Rivers’s return to action in Week 15. With his passes lacking a bit of zip, it’s ...

Philip Rivers and the Indianapolis Colts are attempting to stay alive in the AFC playoff race on Monday night when they host the San Francisco 49ers. Brock Purd ...