Proteases represent a vital class of enzymes that hydrolyse peptide bonds, thereby converting complex proteins into smaller peptides and amino acids. Microbial systems have emerged as an attractive ...

A new AI model designs peptides (short proteins) that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these peptides can act as sensors that ...

Scientists have long struggled to target proteins that lack defined structure and are involved in cancer, neurodegenerative disorders like Parkinson's disease, and other serious illnesses. Now, a new ...

The main protease of SARS-CoV-2 (M PRO) is essential to viral replication, being highly conserved from SARS-CoV-1 through to SARS-CoV-2 and its variants. It has therefore been widely explored as a ...

AMSBIO (Oxford, UK), in association with Nordmark Biochemicals (Uetersen, Germany), has expanded its range of collagenase and neutral protease enzymes with Good Manufacturing Practice (GMP)-grade ...

Bottom: The gray globe indicates the hydrophobic binding pocket in the protease enzyme where telaprevir binds. To keep this as simple as possible, hydrophobic (water-hating, oil-loving) pockets in ...