USA Today's NFL experts make their picks for a Week 17 showdown between the Atlanta Falcons and Los Angeles Rams ...

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night ...

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP ...

The Colts played it safe through the air in Rivers’s return to action in Week 15. With his passes lacking a bit of zip, it’s ...

Monday Night Football player prop projections from Covers. Our best MNF computer picks for 49ers vs. Colts tonight.

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

The SportsLine projection model has revealed its Indianapolis Colts vs. San Francisco 49ers picks for the 2025 NFL Week 16 ...

Tonight’s week 16 MNF game features two teams heading in opposite directions. In the first half of the season, the 49ers ...

San Francisco 49ers tight end George Kittle grabs a 17-yard pass from quarterback Brock Purdy. Highlights from the Week 16 ...

Head Coach Kyle Shanahan and the Niners now control their fate in their pursuit of the NFC West crown and the top overall ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...